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BRD-6929
An HDAC1 and HDAC2 inhibitor
Tucidinostat
An HDAC inhibitor
Tenovin-6 Hydrochloride
A small molecule activator of p53
Tefinostat
Tefinostat (CHR-2845) 是一种单核细胞/巨噬细胞靶向的 HDAC 广谱抑制剂,通过细胞内酯酶人羧酸酯酶-1 (hCE-1) 切割成活性酸 CHR-2847。具有抗抗单核细胞系白血病活性。
SIS17
SIS17 is a mammalian histone deacetylase 11 (HDAC 11)-specific inhibitor with IC50 of 0.83 μM. SIS17 inhibits the demyristoylation of HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs.
Procyanidin B3
A polyphenol flavonoid dimer with diverse biological activities
Nanatinostat
Nanatinostat (CHR-3996) 是一种有效的,有口服活性、I 类选择性的组蛋白去乙酰化酶 (HDAC) 抑制剂,IC50 值为 8 nM。
Domatinostat
Domatinostat (4SC-202) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. Also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). Phase 1.
7,4'-Dihydroxyflavone
A flavonoid with diverse biological activities
ACY-1083
ACY-1083是一种可渗透脑的选择性HDAC6抑制剂,IC50为3nM,ACY-1083对HDAC6的选择性比其他类别的HDAC亚型高260倍。ACY-1083可有效逆转化疗引起的周围神经病变。
BRD 4354
BRD4354是HDAC5和HDAC9适度抑制剂,其IC50值分别为0.85,1.88μM。
HDAC6-IN-1
SKLB-23bb is an orally bioavailable HDAC6-selective inhibitor with IC50 values under 100 nmol/L, against most of the cell lines checked. It also has microtubule-disrupting ability.
Remetinostat (SHP-141)
Remetinostat (SHP-141) (SHP-141) 是一种基于异羟肟酸的组蛋白脱乙酰酶 (HDAC) 抑制剂,正在开发用于治疗皮肤 T 细胞淋巴瘤。
Givinostat hydrochloride (ITF-2357 hydrochloride)
HDAC inhibitor with anti-inflammatory and antineoplastic activities
BEBT-908 (PI3Kα inhibitor 1)
BEBT-908 (PI3Kα inhibitor 1) (PI3Kα inhibitor 1) 是一种选择性 PI3Kα从专利US/20120088764A1中提取的抑制剂化合物243,IC50<0.1 μM, PI3Kα抑制剂 1 还抑制 HDAC (0.1 μM≤IC50≤1 μM)。