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ML-211
A dual inhibitor of lysophospholipase 1 and 2
Cy3 alkyne (non-sulfonated)
used for Click chemistry to label any molecule bearing azide group.
GNE-617 hydrochloride
A potent Nampt inhibitor
AD57 (hydrochloride)
A polypharmacological cancer therapeutic
GSK2807 Trifluoroacetate
GSK2807 Trifluoroacetate 是一种有效的、选择性的、SAM 竞争性的 SMYD3 抑制剂,Ki 为 14 nM,IC50 为 130 nM。
Daratumumab
Daratumumab (DARA) is a human IgG1 mAb targeting CD38, a 46-kDa type II transmembrane glycoprotein that is expressed at high levels on malignant cells in multiple myeloma (MM) [1,2].
7-Methylguanosine
A methylated form of guanosine
MAPK13-IN-1
MPAK13-IN-1是MAPK13(p38δ)的一个抑制剂,其IC50值为620nM。
FR 167653 free base
FR-167653是一种选择性的p38MAPK抑制剂。
GNE-781
GNE-781 (compound 19) is an orally active, highly potent and selective bromodomain inhibitor of cyclic adenosine monophosphate response element binding protein (CBP) with IC50 of 0.94 nM in TR-FRET assay. GNE-781 also inhibits BRET and BRD4(1) with IC50 o
Rpn11-IN-1
Rpn11-IN-1是一种有效的选择性蛋白酶体亚基Rpn11抑制剂,IC50为390nM。
FR 167653 (FR 167653 sulfate)
FR 167653 (FR 167653硫酸盐) (FR 167653 (FR 167653硫酸盐)),一种具有口服活性和选择性的p38 MAPK抑制剂,是TNF-α的强效抑制剂;和 IL-1β;通过特异性抑制 p38 MAPK 活性产生。
Belvarafenib
An inhibitor of B-RAF and C-RAF
CF53
CF53是一种高效、选择性、可口服的BET抑制剂,对BRD4BD1的Ki值为<1nM,Kd值为2.2nM,IC50值为2nM;CF53对BRD2,BRD3,BRD4和BRDTBET蛋白的BD1和BD2两个结构域都有高亲和性,对其选择性远高于非含溴结构域BET蛋白。CF53在体外和体内都具有显著的抗肿瘤活性[1]</su
RMC-4550
A SHP-2 inhibitor