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D-I03
D-I03 is a selective inhibitor of RAD52 with Kd of 25.8 ?M. D-I03 inhibits ssDNA annealing by RAD52 and D-loop formation with IC50 of 5 ?M and 8 ?M, respectively.
iRucaparib-AP6
iRucaparib-AP6 是高效且特异的 PARP1 降解剂,基于 Rucaparib (PROTAC 的方法)。 iRucaparib-AP6 是一种 非捕获性 PARP1 降解剂,可同时阻断 PARP1 的催化活性和支架作用。
COH34
COH34 是一种有效且特异性的聚 (ADP-核糖) 糖水解酶 (PARG) 抑制剂,IC50为 0.37 nM。COH34 与 PARG 的催化结构域 (Kd= 0.547 μM) 结合,从而延长了 DNA 损伤处的 PARylation 并捕获了 DNA 修复因子。
RBN-2397
A PARP7 inhibitor
6(5H)-Phenanthridinone
An inhibitor of PARP1 and 2
AZ9482
A PARP inhibitor
CAY10753
A TNKS2 inhibitor
CAY10760
An inhibitor of the RAD51-BRCA2 interaction
m-Methoxybenzamide
Olaparib-d4
A neuropeptide with diverse biological activities
PARPi-FL
Potent fluorescent PARP inhibitor; cell permeable
Biotin-LC-NAD+
Biotinylated analog of β-NAD+; commonly used reagent in LSD1 and PARP1 assays
Fluorescein-NAD+
荧光素-NAD+ 是放射性标记的 NAD 的替代品,也是 ADP 核糖基化的底物。
NH2-PEG7
NH2-PEG7是一种PROTAClinker(PROTAClinker),属于PEG类。NH2-PEG7可用于PROTACPARP1降解剂iRucaparib-AP6的合成。
SP-8356
SP-8356, an anti-inflammatory synthetic verbenone derivative, is a CD147 inhibitor with respect to its regulation of breast cancer cell behavior and cancer progression.